Translation: Dementia and Anti-Stress – On Brain Detoxification
While care is said to be crucial in managing dementia, the fast-paced nature of modern society often strips away the peace of mind required to truly “wait” and “be present” with patients.
The government’s goal of creating a cohesive society with dementia patients and fostering social participation remains a mere pie in the sky;
it is difficult to resolve the hardships of dementia through communication alone.
Physiologically speaking, we believe that the most vital approach to dementia is to restore the human body’s natural,
instinctive system — by improving blood flow and removing the waste (amyloid-beta) that accumulates in the brain.
In short, the most critical factor is the removal of amyloid-beta, the waste product in the brain that causes dementia.
This is a highly fundamental theory that aligns with the latest research on approaches to preventing and removing amyloid-beta accumulation.
Below are the specific key points to restore this inherent, natural human system and promote the brain’s “waste disposal (detoxification)” and “blood flow”.
- Brain Detoxification: Clearing Amyloid
The key is to enable the “glymphatic system,” which flushes out waste from the brain, to function properly.
- High-Quality Sleep: The clearing of brain waste primarily occurs during sleep.
- Side-Sleeping: Research suggests that sleeping on your side is more efficient at clearing brain waste than sleeping on your back.
- Securing Fasting Time: “Autophagy (self-eating),” which is activated during fasting, helps clean up waste inside cells.
- Improving Blood Flow: Supplying Oxygen and Nutrients to the Brain
Promoting the activation of brain cells by optimizing physical circulation.
- Rhythmic Exercise: Regular rhythmic exercises, such as walking, increase blood flow and boost brain-derived neurotrophic factor (BDNF).
- Mastication (Chewing): Chewing thoroughly is the easiest way to directly increase blood flow to the brain.
- Calf Care: Activating the “second heart” to maintain the pump function that returns blood from the lower body back to the brain.
- Restoring Instinctive Systems: Stimulating the Five Senses
Reclaiming the “senses” that tend to become numbed by a hectic modern lifestyle.
- Deep Breathing (Vagus Nerve Activation): Shifts the body into a parasympathetic-dominant state, causing blood vessels to dilate.
- Contact with Nature: Natural stimuli perceived through sight and smell lower stress hormones and suppress brain inflammation.
- Digital Detox: Prevents “brain fatigue” caused by information overload, creating the mental space for the brain to exert its inherent processing capabilities.
“Anti-Stress” by the Wakan Shoyaku Research Institute consists of ingredients that directly target the two major pillars of dementia prevention: “sleep quality” and “blood flow improvement”.
- Rafuma (Apocynum venetum): Sleep Quality and “Brain Waste Disposal”
Rafuma is a medicinal herb reported to increase the proportion of non-REM sleep (deep sleep).
- Amyloid Clearance: Amyloid, a waste product of the brain, is primarily discharged out of the brain during “deep sleep”.
- Serotonin Regulation: By inhibiting the breakdown of serotonin (often called the happiness hormone), it helps stabilize mood. Consequently, it holds promise for alleviating anxiety, which is a Behavioral and Psychological Symptom of Dementia (BPSD).
- Reishi Mushroom (Kuroyakki / Carbonized): Microcirculation and Repair of Blood Flow
Reishi mushroom (specifically the carbonized kuroyaki component), which has been studied for many years by the Wakan Shoyaku Research Institute, is classified as a “superior medicine (highest rank)” for improving blood flow.
- Improving Microcirculation: It promotes blood flow in the microscopic vessels that run through every corner of the brain, delivering oxygen and nutrients to neurons.
- Neuroprotection: Recent studies suggest that components in Reishi may suppress amyloid deposition and reduce neuroinflammation.
- Characteristics of Kuroyaki (Carbonization): Carbonizing the ingredient concentrates and activates its components, which is believed to support “circulation” at a deeper level.
In addition to these, “Anti-Stress” is formulated with Ginkgo Biloba extract, which is widely known as an ingredient that helps improve cerebral blood flow.
In this “hectic era,” leveraging the wisdom of traditional Japanese and Chinese medicine (Wakan) to optimize the “brain’s cleaning system (sleep)” and the “nutrient supply system (blood flow)” is truly an effective approach to reclaiming human beings’ natural, inherent instincts.
*Note: The Glymphatic System
The glymphatic system is the brain’s waste clearance system that utilizes cerebrospinal fluid (CSF) during sleep to flush out waste products from the brain, such as amyloid-beta, which causes Alzheimer’s disease. Facilitated by the function of astrocytes, it becomes highly active primarily during non-REM sleep and plays an indispensable role in maintaining brain health and function.
Mechanism and Role of the Glymphatic System
- The Brain’s “Lymphatic” Function: Because the brain lacks traditional lymphatic vessels, this system acts in place of the lymphatic system to remove waste products from between brain cells.
- Activation During Sleep: Its functionality increases dramatically during deep sleep (particularly non-REM sleep), where cerebrospinal fluid flows into the brain parenchyma to clear waste from around the veins.
- Waste Clearance: It transports and excretes substances like amyloid-beta and tau proteins, which are causative factors of Alzheimer’s dementia.
Ways to Activate and Maintain It
- High-Quality Sleep: Since a lack of sleep leads to the accumulation of waste, getting sufficient sleep is paramount.
- Proper Hydration: Water is the raw material for cerebrospinal fluid; therefore, dehydration can potentially lead to a decline in the system’s efficiency.
- Caffeine and Catechin Intake: Components found in coffee and green tea support vascular function and blood circulation within the brain.
If this system malfunctions, the chronic accumulation of waste products is believed to increase the risk of dementia and Idiopathic Normal Pressure Hydrocephalus (iNPH).
For the recovery, normalizing microcirculation is highly efficacious.
We found dosing proper amount of reishi, a gift of nature, is essential for better microcirculation.
KOUKA is a processed food product of Ganoderma Lucidum (reishi), patented in Japan as a composition of matter to ameliorate cognitive dysfunctions.
Almost 100% of KOUKA users who took it for 4 months experienced alleviation of cognitive dysfunctions and life style diseases.
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